Decreased NOS1 Expression in the Anterior Cingulate Cortex in Depression

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism

BACKGROUND Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we examined the postmortem brains of people with autism to identify any changes in the expression of axon-guidance proteins. RESULTS The mRNA and protein expression of axon-guidanc...

متن کامل

Reduced somatostatin in subgenual anterior cingulate cortex in major depression.

Converging evidence suggests a central role for dysfunction of the subgenual anterior cingulate cortex (sgACC) in the pathophysiology of major depressive disorder (MDD). Underlying mechanisms may include altered GABAergic function. Expression of somatostatin (SST), an inhibitory neuropeptide localized to a subset of GABA neurons, has been shown to be lower in the dorsolateral prefrontal cortex ...

متن کامل

Application of magnetic resonance spectroscopy for evaluating metabolic alteration in anterior cingulate cortex in Alzheimer's disease

Introduction: Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Mild cognitive impairment (MCI) is often the prodromal stage to AD. Most patients with MCI harbor the pathologic changes of AD and demonstrate transition to AD at a rate of 10–15% per year. Accumulating evidence indicates that the asymmetry changes of left and right brain have happened in the early stage of A...

متن کامل

Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly.

BACKGROUND Neuroimaging studies have demonstrated changes in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in major depression. AIMS We investigated the expression of cell adhesion molecules (CAMs) in the prefrontal cortex in depression. METHOD Immunohistochemistry to localise CAMs in post-mortem tissue from 20 subjects with major depression and 20 controls,...

متن کامل

Anterior cingulate cortex in schema assimilation and expression.

In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMP...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Cerebral Cortex

سال: 2012

ISSN: 1460-2199,1047-3211

DOI: 10.1093/cercor/bhs285